Buying SAMe 400 mg (20 Tabs) | Life Extension | Brain, Mood, Joint, & Liver Support

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SAMe 400 mg (20 Tabs) | Life Extension | Brain, Mood, Joint, & Liver Support

SAMe (S-Adenosyl-Methionine) from Life Extension promotes a positive and well balanced mood, helps maintain joint elasticity and mobility, and protects the liver and brain..

Ingredients & Description

SAMe, short for S-adenosyl-methionine, is a coenzyme which is naturally synthesized in the body.  Discovered in 1952, SAME has been found to play essential rolls in three metabolic processes within the body including polyamine synthesis, methylation, and trans-sulfuration, Essentially, SAMe has been found to promote healthy cell growth, gene expression, nerve regeneration, and aid in molecular activation and synthesis.  It has also been found to help prevent neurodegenerative diseases such as dementia, and Alzheimer’s Disease, and combats depression, osteoarthritis, and certain liver disorders.

SAMe is necessary for the production of hormones, proteins (enzymes), nucleic acids, and neurotransmitters such as dopamine and serotonin.  Recent clinical studies have shown SAMe to be effective in alleviating symptoms of depression, helping to maintain a stable mood and positive attitude.  A study completed in 2002 also found SAMe to help maintain joint function, reducing pain and upholding joint elasticity and integrity. Many other studies also suggest that healthy levels of SAMe can help prevent Alzheimer’s Disease, reducing oxidative stress on/in the brain and retaining cognitive function and ability.


  • Helps Produce Neurotransmitters
    • Dopamine
    • Serotonin
  • Alleviates Symptoms of Depression
  • Improves Mood
  • Reduces Risk of Liver Damage
  • Reduces Pain of Osteoarthritis
  • Joint Elasticity
  • Helps Prevent Alzheimer’s Disease
  • Enteric Coated Tablets for Maximum Absorption & Benefits


For best results take one tablet two to three times daily in divided doses morning, midday, and late afternoon or as directed by your healthcare professional. In some cases doses exceeding 400 mg of SAMe have been found to cause dry mouth, restlessness and gastrointestinal problems. Slowly increasing dosage may help prevent these problems; taking SAMe with food may avoid gastrointestinal upsets. SAMe works well when combined with B12, B6 and Folic Acid.

SAMe is not recommended for people who have been diagnosed with bipolar disorder.

Serving Size: 1 Enteric Coated Tablet
S-Adenosyl-Methionine 400 mg
APS = Amount Per Serving
*% Daily Value (%DV) not established.

Other ingredients: cellulose, mannitol, hydroxypropyl methylcellulose phthalate, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica, titanium dioxide, yellow ochre.

Contains soybeans. Contains yeast.

This product contains NO milk, egg, fish, crustacean shellfish, tree nuts, wheat, peanuts, gluten, corn, or rice. Contains NO sugar, and no artificial sweeteners, colors, flavors, or preservatives.

SKU: 00557
UPC: 737870557029
Distributed or manufactured from Life Extension. See more Life Extension products.
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*Not intended to diagnose or treat diseases or ailments, and is not reviewed by the FDA.

Uses & Indications.
  • Calming Nerves
  • Enhancing Immune Function
  • Increasing Mobility
  • Reducing Stress
  • Relieving Pain
Ailments & Concerns.
  • Alzheimer's Disease
  • Stress
  • Depression
  • Rheumatism
  • Liver Disease
  • Hepatitis C
  • Anxiety
  • Dementia
  • Osteoarthritis

Questions and answers:

    Asked on: January 18, 2013
    Question: can same be taken with food
    • 0 0 A: Thank you for contacting us about SAMe. Yes, taking SAMe with food may avoid gastrointestinal upsets. SAMe works well when combined with B12, B6 and Folic Acid. Vote down - Vote up
    Asked on: February 7, 2013
    Question: why is it reccomended not to take if you have bipolar ??
    • 0 0 A: Thank you for your interest in SAMe. Bipolar disorder is characterized by states of mania and depression. We put the caution on SAMe due to the potential for individuals with bipolar disorder to have an increased risk of experiencing manic episodes. It is important to keep in mind that every individual has a unique biochemical makeup so not every person will respond the same way.

      If an individual has been diagnosed with bipolar disorder, we encourage them to discuss with their doctor before adding nutritional supplements to their regimen. Vote down - Vote up
    Asked on: October 5, 2013
    Question: is this product same as Ciroze - 400 which is available in India
    • 0 0 A: This SAMe is not related to Ciroze but comes from the manufacturer Life Extensions. Vote down - Vote up

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