Ingredients & DescriptionJarrow Formulas pharmaceutical grade, stabilized SAM-e JOINT provides a full 200 mg SAM-e (net yield) and 525 mg of Glucosamine hydrochloride in every enteric-coated tablet. SAM-e JOINT is manufactured under low temperature and low humidity and is enteric-coated to ensure a biologically active product. SAM-e and Glucosamine are known to benefit joint function and recuperation.
Found in all living cells, SAM-e is a metabolite of methionine (an essential amino acid).SAM-e is a chiral molecule and consists of two forms: (S,S) SAM-e and (R,S) SAM-e. The biologically active form is the (S,S) structure, while the (R,S) structure is biologically inactive. Jarrow Formulas SAM-e is made naturally by microbiological fermentation and then specially processed without solvents to preserve 68-80% (S,S) SAM-e, the highest active level available.
Glucosamine is an aminosaccharide synthesized by transamidase enzymes from glucose and an amine group from glutamine. HCl (hydrochloric acid) stabilizes the Glucosamine in this product. Glucosamine is a component of joint and intestinal tissue and is involved in the production of synovial fluid that lubricates the joints.*
SAM-e has been clinically shown to have the following benefits:
SAM-e supports the production of healthy connective tissue through transulfuration.* In this process, critical components of connective tissue, including glucosamine and the chondroitin sulfates, are sulfated by SAM-e metabolites.*
SAM-e methylation reactions are involved in the synthesis of neurotransmitters such as L-DOPA, dopamine and related hormones, epinephrine and phosphatidylcholine (a component of lecithin).*
Methylation of DNA appears to be important in the suppression of errors in DNA replication. Demethylation of DNA is considered a contributor to the aging process.* Proper methylation through substances such as SAM-e positively influences longevity.*
SAM-e metabolism supports the synthesis of glutathione (GSH) and glutathione-dependent enzymes (glutathione peroxidase and glutathione-S-transferase), which are substances important for liver function.*
Take 1 to 2 tablets per day on an empty stomach, or as directed by your qualified health care consultant. Full potency 200 mg SAM-e is derived from 400 mg of SAM-e tosylate disulfate. Jarrow Formulas SAM-e JOINT is Joint Sustain nutrition, providing glucosamine HCI, a SODIUM FREE form of glucosamine. For best results, use with Jarrow Formulas JarroSil, the biologically Activated Silicon.
Longevity*, Joint Strength*, Liver Detoxification*, Mood and Brain Function*
Store in a cool, dry place.
Keep out of the reach of children.
Warning: Do not use if allergic to shellfish. Individuals using prescribed medications such as antidepressants, including Selective Serotonin Re-Uptake Inhibitors (SSRIs) and MAO Inhibitors should consult a physician before using. Individuals with Parkinson's disease, bi-polar disorder or manic depression should not use SAM-e. Jarrow Formulas SAM-e JOINT is foil blister-packed to maximize stability and safety. Do not use if seal of blister pack is broken.