Indomethacin | Prescription Drug Details, Risks & Natural Alternatives
Also indexed as: Indocin
Indomethacin is a member of the non-steroidal anti-inflammatory drug (NSAIDs) family of drugs. NSAIDs reduce inflammation (swelling), pain, and temperature. Indomethacin is used to reduce pain/swelling involved in osteoarthritis, rheumatoid arthritis, bursitis, tendinitis, gout, ankylosing spondylitis, and headaches.
Summary of Interactions with Vitamins, Herbs, and Foods
In some cases, an herb or supplement may appear in more than one category, which may seem contradictory. For clarification, read the full article for details about the summarized interactions.
 May Be Beneficial: Depletion or interferenceThe medication may deplete or interfere with the absorption or function of the nutrient. Taking these nutrients may help replenish them. |
Calcium* Folic acid Vitamin C |
 Avoid: Adverse interactionAvoid these supplements when taking this medication because taking them together may cause undesirable or dangerous results. |
Lithium* Potassium Sodium White willow* |
 Check: OtherBefore taking any of these supplements or eating any of these foods with your medication, read this article in full for details. |
Iron |
| Side effect reduction/prevention |
None known |
| Supportive interaction |
None known |
| Reduced drug absorption/bioavailability |
None known |
An asterisk (*) next to an item in the summary indicates that the interaction is supported only by weak, fragmentary, and/or contradictory scientific evidence.
Interactions with Dietary Supplements
Iron
Iron supplements can cause stomach irritation. Use of iron supplements with indomethacin increases the risk of stomach irritation and bleeding.1 However, stomach bleeding causes iron loss. If both iron and indomethacin are prescribed, they should be taken with food to reduce stomach irritation and bleeding risk.
Lithium
Lithium is a mineral that may be present in some supplements and is also used in large amounts to treat mood disorders such as manic-depression (bipolar disorder). Most NSAIDs inhibit the excretion of lithium from the body, resulting in higher blood levels of the mineral, though sulindac may have an opposite effect.2 Since major changes in lithium blood levels can produce unwanted side effects or interfere with its efficacy, NSAIDs should be used with caution, and only under medical supervision, in people taking lithium supplements.
Potassium
Indomethacin may cause elevated blood potassium levels in people with normal and abnormal kidney function.3 4 5 6 Until more is known, people taking indomethacin should not supplement potassium without medical supervision.
Vitamins and minerals
Indomethacin has been reported to decrease absorption of folic acid and vitamin C.7 Under certain circumstances, indomethacin may interfere with the actions of vitamin C.8 Calcium and phosphate levels may also be reduced with indomethacin therapy.9 It remains unclear whether people taking this drug need to supplement any of these nutrients.
Sodium
Indomethacin may cause sodium and water retention.10 It is healthful to reduce dietary salt intake by decreasing the use of table salt and avoiding heavily salted foods.
Interactions with Herbs
White willow bark (Salix alba)
White willow bark contains salicin, which is related to aspirin. Both salicin and aspirin produce anti-inflammatory effects after they have been converted to salicylic acid in the body. The administration of salicylates like aspirin to individuals taking oral NSAIDs may result in reduced blood levels of NSAIDs.11 Though no studies have investigated interactions between white willow bark and NSAIDs, people taking NSAIDs should avoid the herb until more information is available.
Interactions with Foods and Other Compounds
Food
Indomethacin should be taken with food to prevent stomach irritation.12 However, applesauce, high-protein foods, and high-fat foods have been reported to interfere with indomethacin absorption and/or activity.13
Alcohol
Indomethacin may cause drowsiness or dizziness.14 Alcohol may amplify these actions. Use of alcohol during indomethacin therapy increases the risk of stomach irritation and bleeding.15 People taking indomethacin should avoid alcohol.
