Ingredients & DescriptionBest Acetyl-L-Carnitine consists of Biosint™ Acetyl-L-Carnitine, which is manufactured in Italy by the Sigma Tau company. It is derived from a base of pharmaceutical-grade L-Carnitine manufactured using an FDA-approved process that fully complies with international monograph standards for carnitine production. Known as a global leader in L-Carnitine research, Sigma Tau holds numerous patents for production of L-Carnitine, and its L-Carnitine derivatives, such as ALC, which are used in clinical trials.
Acetyl-L-Carnitine (ALC) is a naturally occurring form of L-Carnitine, a vitamin-like nutrient synthesized in the body from the amino acids lysine and methionine. ALC serves as a transport molecule for "active acetate," which is a source of fuel for metabolic processes that take place in cells. ALC carries active acetate (the "Acetyl" portion) directly into the mitochondrion, the cell's energy-generating structure. Active acetate is used to produce cellular energy in the form of ATP. Both L-Carnitine and ALC serve as fat carriers. Unlike L-Carnitine, ALC readily crosses the blood-brain barrier, where it has specific benefits for brain neurons. When taken orally, ALC has been shown to increase ALC levels in both blood and cerebrospinal fluid, demonstrating its uptake in the brain.1
ALC has been studied for its effect on cognitive performance and emotional health in the elderly. Elderly people taking ALC while hospitalized have shown improvements in mental outlook.2 While ALC is not a treatment or cure for Alzheimer's disease, double-blind studies suggest it may help slow the rate at which early-stage Alzheimer's patients deteriorate.4 In particular, ALC seems to benefit short-term memory in these patients.5
Best Acetyl L-Carnitine
Serving Size: 1 capsule
|Acetyl-Carnitine (from 588 mg acetyl-l-carnitine HCI supplied by Sigma tau)||500 mg||†|
† Daily Value not established.
Other Ingredients: Stearic acid, cellulose, magnesium silicate, silicon dioxide, gelatin capsule.
Suggested Adult Use: 1 to 4 capsules daily.DOES NOT CONTAIN: milk, egg, wheat, corn, sugar, sweeteners, starch, salt, or preservatives. Contains nothing other than listed ingredients.
*These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.
1 Pettegrew, JW, Levine, J, McClure, RJ. Acetyl-L-carnitine physical-chemical, metabolic, and therapeutic properties: relevance for its mode of action in Alzheimer's disease and geriatric depression. Molecular Psychiatry 2000;5:616-32.
2 Tempesta, E, et al. L-acetylcarnitine in depressed elderly subjects. A cross-over study vs. placebo. Drugs Exptl. Clin. Res. 1987;8(7):417-23.
3Spagnoli, A et al. Long-term acetyl-L-carnitine treatment in Alzheimer's disease. Neurology 1991;41:1726-32.
4Rai, G et al. Double-blind, placebo-controlled study of acetyl-L-carnitine in patients with Alzheimer's dementia. Curr. Med Res. Opin. 1990;11:638-47.
*Not intended to diagnose or treat diseases or ailments, and is not reviewed by the FDA.Uses & Indications.